MSCs – Regenerative
Mesenchymal stem cells (MSCs) are multipotent stromal cells capable of regulating inflammation, supporting tissue repair, and restoring local tissue homeostasis. Rather than permanently engrafting into damaged tissues, MSCs primarily act through paracrine signaling — releasing bioactive molecules that influence immune cells, fibroblasts, endothelial cells, and resident progenitor cells. Their mechanisms of action include modulation of macrophage polarization, suppression of excessive inflammatory cytokines, promotion of angiogenesis, and support of extracellular matrix remodeling. In veterinary medicine, MSC-based therapies are increasingly explored in osteoarthritis, tendon injuries, dermatological disorders, ophthalmology, and chronic inflammatory diseases. References: Caplan & Correa, 2011; Harman et al., 2016; Cabon et al., 2019.
Date:
2022-11-09
Category: